Oral squamous cell carcinoma SlideShare

• Oral cancer constitutes 12% of all cancers in men and 8% of all cancers among women. • Oral cancer is one of the 10 most common causes of death. • There is a slight Male predilection, with a male to female ratio of 1.7:1. 7. • Squamous cell carcinoma is the most common, representing 90- 95% of all oral malignancies. • The overall 5-year survival rate for oral cancer has increased from 45-53% from 1960 s squamous cell carcinoma epithelial carcinoma scc oral cancer Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website Slideshow search results for oral squamous cell carcinoma Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website It is one of the main types of skin cancer. SCCs often look like scaly red patches, open sores, elevated growths with a central depression, or warts; they may crust or bleed. SCCs may occur on all areas of the body including the mucous membranes and genitals, but are most common in areas frequently exposed to the sun, such as the rim of the ear, lower lip, face, balding scalp, neck, hands, arms and legs. Most lip and oral cavity cancers start in squamous cells, the thin, flat cells that line. Spindle cell carcinoma a rare subtype of squamous cell carcinoma usually develops in sun-exposed areas in lightly- pigmented individuals older than 40 years of age. The prognosis primarily depends on the depth of invasion Verrucous and spindle cell carcinomas are managed similar to more conventional squamous cell carcinomas. 24

Nodular basal cell carcinoma most common begins as a small, slightly elevated papule with a central depression which ulcerates, heals over and then breaks down again Very mild trauma may cause bleeding One or more telangiectatic blood vessels are usually seen coursing over the borders around the central depression It enlarges, but still evidences periods of attempted healing Eventually, develops a smooth, rolled border representing tumor cells spreading laterally beneath the skin Untreated. Squamous cell carcinoma accounts for 90% of all oral cancers. It may affect any anatomical site in the mouth, but most commonly the tongue and the floor of the mouth. It usually arises from a pre-existing potentially malignant lesion, and occasionally de novo; but in either case from within a field of precancerized epithelium. The use of tobacco and bete The slides were evaluated for positivity and intensity of staining. Statistical analysis: The result was subjected to statistical analysis using Fisher's exact test. Results: α-SMA expression in the stroma of squamous cell carcinoma was greater than its expression in epithelial dysplasia and normal oral mucosa

Squamous Cell Carcinoma (SCC) of Oral Cavity is a common malignant tumor of the mouth that typically affects elderly men and women. It is more aggressive than conventional squamous cell carcinoma affecting other body regions. The cause of the condition is unknown, but genetic mutations may be involved D. Jeffress Good oral hygiene may help prevent oral squamous cell carcinoma. Oral squamous cell carcinoma is the most common form of mouth cancer that is usually caused by excessive alcohol and tobacco use. Cancer of the mouth usually manifests as small discolored lesions on the tongue, gums, inner lips, or the floor or roof of the mouth occur in the head and neck. Oral squamous cell carcinomas of the lip are more common in transplant recipients receiving immunosuppressive therapy, but HIV infection does not predispose to intra-oral squamous cell carcinoma.[29] Candida Candida albicans can induce epithelial proliferation and can produce carcinogens from procarcinogens in vitro



  1. Squamous cell carcinomas, also known as epidermoid carcinomas, comprise a number of different types of cancer that result from squamous cells. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts. Common types include: Squamous cell skin cancer: A type of skin cancer Squamous-cell carcinoma of the lung: A type of lung cancer Squamous cell thyroid carcinoma: A type of thyroid cancer Esophageal squamous
  2. grades of oral squamous cell carcinoma. Materials and Methods: A cross sectional study was conducted on fifty cases of oral squamous cell carcinoma. The specimen were collected from the department of Oral & Maxillofacial Surgery and processed for hematoxylin and eosin stain and AgNOR stain Pathology Laboratory, King Edward Medical University Lahore
  3. Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm that affects the oral cavity . Significant risk factors for SCC include smoking and alcohol consumption. Early detection by clinicians is crucial for improved outcomes and survival

'oral squamous cell carcinoma' on SlideShar

  1. Oral squamous cell carcinoma (OSCC) is a major head and neck cancer and has negative effects on the quality of life and survival of patients. 1 Although new diagnosis and therapeutic modalities.
  2. Focused Epithelial Pathology with stained slides of pathology. Follow us: 11128 Images : Last Website Update : Jun 9, 2021. Squamous Cell Carcinoma of Oral Cavity. Squamous Cell Carcinoma : Tongue. Squamous Cell Carcinoma : Lip. Verrucous Carcinoma. Verrucous Carcinoma
  3. Introduction. The vast majority of oral cancers are squamous cell carcinomas (OSCC). The effectiveness of adjuvant cytostatic chemotherapy for OSCC is frequently restricted due to an inducible cellular mechanism called multidrug resistance (MDR) and a putative cancer stem cell (CSC) compartment in human carcinogenesis expressing multidrug efflux pumps
  4. Squamous cell carcinoma (SCC) is the most frequent tumour in this location, representing 91% of all head and neck malignancies and 90% of oral malignant tumours1, 2. Despite improved diagnostic techniques, as well as new therapies and protocols, the 5-year survival rate remains around 50-60% 3

Squamous cell carcinoma - SlideShar

  1. Oral squamous cell carcinoma (OSCC) is the most common type of oral neoplasm, accounting for over 90% of all oral malignancies and 38% of head and neck tumors. Worldwide, OSCC is the eighth most common human cancer, with more than 500,000 new cases being diagnosed every year with a fairly onerous pr
  2. Introduction. Head & neck squamous cell carcinoma is the fifth most common malignant neoplasm which arises from diverse anatomical locations including oral cavity, oropharynx, larynx & hypopharynx [].In India cancer registries have confirmed a high evidence of oral cancer due to widespread habits of tobacco chewing, smoking and alcohol consumption []
  3. Squamous Cell Carcinoma. Home Head & Neck Larynx Squamous Cell Carcinoma. Squamous Cell Carcinoma - Epiglottis. Squamous Cell Carcinoma - Epiglottis. Advertisement. Tweets by @WebPathology
Oral cancer

Squamous cell carcinoma skin - SlideShar

Basal cell carcinoma of oral cavity - SlideShar

Laryngeal squamous cell carcinoma remains one of a few subsite that is likely to be detected at earlier stages due to the presenting symptom of persistent hoarseness, which can occur with mild alterations of the vibratory surfaces of the true vocal cords. From: Essentials of Genomic and Personalized Medicine, 2010. Download as PDF oral squamous cell carcinoma; Oral squamous cell carcinoma (OSCC) represents the most malignant neoplasm in oral cancer with a mortality rate of more than 50%. The OSCC is a multistep neoplasia initially developed from mild oral epithelial hyperplasia to dysplasia followed by carcinoma in situ

Oral squamous cell carcinoma (OSCC) is the common oral carcinoma with varied clinical presentations. It accounts for more than 90% of all malignant lesions in the oral cavity [ 2. M. L. Wallace and B. W. Neville, Squamous cell carcinoma of the gingiva with an atypical appearance, Journal of Periodontology, vol. 67, no. 11, pp. 1245-1248. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification Chiou, S. H. et al. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin. Cancer Res. 14 , 4085-4095 (2008)

Oral squamous cell carcinoma (OSCC) represents 95% of all forms of head and neck cancer, and over the last decade its incidence has increased by 50%. Oral carcinogenesis is a multistage process, which simultaneously involves precancerous lesions, invasion and metastasis. Degradation of the cell cycle and the proliferation of malignant cells results in the loss of control mechanisms that ensure. Most skin squamous cell cancers are slow growing and rarely metastisize untill they get large. Those in the lip or oral cavity are much more aggressive. There is one type of squamous cell carcinoma that grows rapidly (weeks and months) and forms a volcano like lesion with a central depression in its classic form called keratoacanthoma.A lesion. Design: Forty cases of oral cavity squamous cell carcinoma in which the status of perineural and vascular invasion had been part of the original pathology report were reviewed. All original routinely stained slides were reviewed as well as S100- and CD31-stained sections of each case's tissue blocks that contained tumor Squamous cell carcinoma is the most common malignant oral tumor in cats, accounting for 60% of such tumors.1 Fibrosarcoma is the second most common malignant oral tumor, with lymphoma, melanoma, adenocarcinoma, chondrosarcoma, granular cell tumors, fibropapilloma, hemangiosarcoma, osteosarcoma, and mast cell tumors occurring less frequently.1,6. Introduction. Oral squamous cell carcinoma (OSCC), whose risk factors include alcohol use, tobacco exposure, continued stimulation (areca chewing, for instance), and virus infection, is the most common malignancy among oral cancers [1-3].The high invasiveness of tumor cells is responsible for the tendency of recurrence and lymph node metastasis in OSCC []

Squamous cell carcinoma of the oral cavity and pharynx accounts for over 48,250 cases per year in the United States with approximately 9,575 deaths per year(1,2). Unfortunately, the diagnosis continues to rely on patient presentation and physical examination with biopsy confirmation. This may result in delay in diagnosis accounting for the fact. Oral cancer is a commonly occurring one worldwide. More than 90% of all oral cancers are squamous cell carcinoma (SCC). The molecular biological markers of oral SCC have been extensively studied to aid in prevention and prognosis. However, no marker has been universally accepted so far. Mast cells a

Myofibroblasts as important diagnostic and prognostic

Squamous Cell Carcinoma of Oral Cavit

Squamous Cell Carcinoma Causes. Exposure to ultraviolet (UV) rays, like the ones from the sun or a tanning bed, affects the cells in the middle and outer layers of your skin and can cause them to. The TNM staging system of oral squamous cell carcinoma (OSCC) has historically provided clinicians a dependable foundation for patient prognosis and management decisions. Generally, the relative risk of neck lymph node metastasis of T1 and T2 tumors is 10% and 30%, respectively, whereas that of T3 and T4 tumors is distinctly higher [ 1 , 2 ] Squamous Cell Carcinoma. Description - Cutaneous squamous cell carcinoma or actinic keratosis is a malignant tumor of epidermal cells in which cells show differentiation in keratinocytes (it is the major constituent of the epidermis, constituting 95% of the cells found there).It accounts for 5% of all cutaneous tumors found in dogs. These tumors generally grow slowly, but are aggressive in.

Squamous Cell Carcinoma - Epiglottis. Advertisement. Tweets by @WebPathology Purpose: The aim is to investigate the impacts of using multiplex immunochemistry (mIHC) staining to analyses the co-expression of programmed death ligand-1 (PD-L1) and tumor infiltrating lymphocytes (TILs) [CD8 + T cells and Forkhead Box Protein 3 (FOXP3) + regulatory T cells (Tregs)] in different oral diseases, and oral squamous cell carcinoma (OSCC) Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are the main causes to. Patients diagnosed with histological variants of squamous cell carcinoma (SCC) or recurrent tumor were excluded. Three hundred forty-eight touch imprint slides were prepared from 174 margins of 30 resected tumor specimens. Imprints from tumor proper were taken as positive controls

Oral squamous cell carcinoma (OSCC), a subset of head and neck cancer, accounts for 355,000 new cancer cases annually worldwide 1 and has a 5-year survival rate of only 50% 2.Current approaches to. Oral squamous cell carcinoma (OSCC) forms a major health problem in many countries. For several decades the management of OSCC consisted of surgery with or without radiotherapy or chemoradiotherapy. Aiming to increase survival rate, recent research has underlined the significance of harnessing the immune response in treatment of many cancers. The promising finding of checkpoint inhibitors as a.

Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide and accounts for more than 95% of head and neck cancers [1, 2].The incidence of OSCC in Taiwan has increased by 30% in the last 5 years, and the mortality rate has increased by 25% [].The behavior of OSCC is aggressive with the propensity for local recurrence and distant metastasis due to innate and acquired. Oral squamous cell carcinoma, the most common type of oral cancer, affects more than 275,000 people per year worldwide. Oral squamous cell carcinoma is very aggressive, as most patients die after 3 to 5 years post-diagnosis. The initiation and progression of oral squamous cell carcinoma are multifactorial: smoking, alcohol consumption, and human papilloma virus infection are among the causes. Oral squamous cell carcinoma (OSCC) is the most common cancer of the oral cavity and constitutes 95% of all cancers of this area. Men are affected twice as commonly as women, primarily if they are over 50 years of age. Forty percent of the lesions are localized in the tongue and 30% in the floor of the oral cavity

Accurate prediction of the behaviour of oral squamous cell carcinoma (OSCC) is necessary to determine prognosis and provide appropriate treatment. Therefore, it is important to investigate potential prognostic markers to determine their predictive ability. Histological assessment of specific features at the invading front of oral squamous cell carcinomas has shown to provide accurate and. HPV is a double-stranded DNA oncovirus and is epitheliotropic, infecting the basal cells of the epithelium and can be found in up to 60% of squamous cell carcinomas of the oropharynx [ 6 ]. There are more than 150 isolated strains of HPV, but only two types 16 and 18 are most commonly linked to oropharyngeal cancers Local resident normal fibroblasts (NFs) are the major source of cancer-associated fibroblasts (CAFs), which are distinguishable from NFs by their tumor-supportive properties. However, the mechanism and the effects underlying the transition of NFs to CAFs in oral squamous cell carcinoma (OSCC) remain unclear. Five pairs of matching primary NFs and CAFs derived from OSCC patients were sent for.

What is Oral Squamous Cell Carcinoma? (with pictures

Oral squamous cell carcinoma (OSCC), very simply put, is a malignant neoplasm of the squamous cell or keratinocyte. Various factors induce DNA mutations in the squamous cell, causing excess proliferation of these cells leading to cancer. OSCC is known to be the most common oral malignancy. It is reported to account for 90% of all cancers. Oral squamous cell carcinomas (SCC) are the most common oral tumor in cats, and second most common in dogs. These tumors are locally aggressive, with a possibility to metastasize. Regardless of the location of SCC, surgery is the typically the standard treatment. Radiation therapy may be recommended following surgery or as a primary treatment for palliative care Oral squamous cell carcinoma (OSCC) is the sixth most common cause of cancer related to death in the world (Warnakulasuriya 2009) and is the most frequent malignancy in the mouth, accounting for up to 90% of all oral malignant lesions (Warnakulasuriya 2009). Despite the advances in surgery and multimodal treatment regimes, th Oral Squamous Cell Carcinoma. Oral cancer refers to cancer occurring between the vermilion border of the lips and the junction of the hard and soft palates or the posterior one third of the tongue. Over 95% of people with oral squamous cell carcinoma smoke tobacco, drink alcohol, or both. Early, curable lesions are rarely symptomatic; thus. 2.1.Oral Squamous Cell Carcinoma Squamous Cell Carcinoma bentuk kedua paling umum dari kanker kulit setelah basal cell carcinoma (BCC). Beberapa kasus yang disebabkan oleh SCC meningkat setiap tahunnya dan tidak menunjukkan adanya tanda tanda penurunan. Squamous Cell Carsinoma adalah kanker kulit yang tumbuh cukup lambat

The accumulating abnormal mouth cancer cells can form a tumor. With time they may spread inside the mouth and on to other areas of the head and neck or other parts of the body. Mouth cancers most commonly begin in the flat, thin cells (squamous cells) that line your lips and the inside of your mouth. Most oral cancers are squamous cell carcinomas To analyze the impact of resection margin status and histologic prognosticators on local recurrence (LR) and overall survival (OS) for patients with oral squamous cell carcinoma (OSCC). This study was both retrospective and prospective in design. Cohort 1 refers to the entire group of 292 patients with OSCC

Video: Oral squamous cell carcinoma: Etiology, pathogenesis and

Oral Squamous Cell Carcinoma - Ear, Nose, and Throat

1 INTRODUCTION. The oral cavity, including the lip, is the sixth most common cancer in the world. 1 Oral squamous cell carcinoma (OSCC) accounts for more than 90% of all oral cancer. 2 OSCC is associated with a poor 5-year survival rate of <50%, and this is due to the spread of OSCC to regional and distant sites. 3 One of the significant features of cancer cells facilitating spread is their. The extracted features combined to produce significant accuracy for tongue squamous cell carcinoma discriminations: Sensitivity: 0.99 Specificity: 0.95 Accuracy: 97.2%: Raman spectroscopy combined with deep learning has a great potential for the intraoperative evaluation of the margin resection of oral tongue squamous cell carcinoma Squamous cell hyperplasia, papilloma, and squamous cell carcinoma of the oral cavity appear to form a continuum. Papillomas are generally larger than hyperplastic lesions but still show orderly cell maturation. A spectrum of lesions may occur in positive carcinogenicity studies, especially when multiple proliferative lesions of the oral mucosa. Oral squamous cell carcinoma (OSCC) is known for its aggressiveness associated with poor prognosis. The molecular mechanisms underlying the invasion and metastasis are still poorly understood. An.

Ilimaquinone Induces Apoptosis and Autophagy in Human Oral

The squamous cell carcinoma is not only the most common oral malignancy of the cat, it carries one of the poorest outcomes. The squamous cell carcinoma often grows from the gums surrounding the teeth or under the tongue. Getting comfortable looking in your cat's mouth is required for fast diagnosis. Because the tumor does not spread until late in its course, removing the tumor when it is small. In large regions of Southeast Asia it is the second most‐diagnosed cancer. The disease is typically found on the surface of the tongue or gingiva, but can occur anywhere in the oral mucosa. Over 90% of oral cancers are oral squamous cell carcinoma (OSCC). While oral lesions are easily detectable by dentists, only a small percentage will be OSCC

HPV-positive Squamous Cell Carcinoma of the Larynx, Oral

Oral cancer is a leading cause of cancer death and oral squamous cell carcinoma is the most common type of oral cancer. Early detection of high-risk premalignancy can decrease the morbidity and mortality associated with oral cancer [ 1 ] Generally, 90 per cent of all oral malignancies exist as oral squamous cell carcinoma (SCC), which globally accounts for an estimated 275 000 new cases per year. Reference Alamgir, Jamal and Mirza 7, Reference Farrukh, Syed and Pervez 8 Despite the relative ease of diagnosis, oral cancer is associated with a low survival rate, of 40-50 per cent The prognosis of advanced oral squamous cell carcinoma (OSCC) remains dismal, but may be improved by multimodal therapy. Advanced OSCC is typically treated by surgery with or without postoperative radiotherapy or chemoradiotherapy based on pathological findings [].Preoperative chemoradiotherapy has been conducted in some centers, and a literature-based meta-analysis indicated no significant. Oral cancer is the sixth most common cancer worldwide. The most common type of oral cancer is squamous cell carcinoma, which accounts for almost nine out of 10 oral malignancies. 1 The prognostic evaluation and decisions on treatment strategy are mainly based on the TNM stage. 2 Despite progress in treatment modalities over the past few decades, oral cancer still has a poor survival rate, with.

Oral Cancer Images - The Oral Cancer Foundatio

Most oral/pharyngeal cancers are oral squamous cell carcinomas (OSCC) (Scully & Bagan, 2009; Bagan et al., 2010). In the United States, the primary risk factors are tobacco, smoking, and elevated levels of alcohol consumption (Jemal et al., 2008) Squamous cell carcinoma (SCC) accounts for more than 90% of the malignant neoplasm's in the oral cavity, which includes tongue, floor of mouth, buccal mucosa, alveolar rim and the hard and soft palate [1, 2].Globally, about 275,000 new cases of oral SCC (OSCC) are diagnosed each year [], but the incidence of OSCC show large geographical variations oral squamous cell carcinoma in vitro Xu Chen1†, Qingqiong Luo1†, Jieying Ding1, Meng Yang1, Ruiyang Zhang1 and Fuxiang Chen1,2* Abstract Oral squamous cell carcinoma (OSCC) is the most common type of head and neck squamous cell carcinoma (HNSCC), and the effect of zymosan (ZYM), a component of the yeast cell wall, on oral cancer remains. Squamous cell carcinoma is a malignant epithelial tumor which originates in epidermis, squamous mucosa or areas of squamous metaplasia. In skin, tumor cells destroy the basement membrane and form sheets or compact masses which invade the subjacent connective tissue (dermis). In well differentiated carcinomas, tumor cells are pleomorphic. Oral squamous cell carcinoma (OSCC) is an aggressive human malignancy. Because of late diagnosis and recurrence of OSCC, the treatment of patients with OSCC is often ineffective. Thus, finding novel biomarkers of OSCC are essential. Here we derived a methylation marker by utilizing methylation microarray data and testing its capacity in cross-sectional study designed for OSCC detection and.

Squamous cell carcinoma - Wikipedi

Oral squamous cell carcinoma (OSCC) has a striking global incidence and equally formidable mortality rates. 1 The worldwide mortality caused by cancer of the oral cavity and lip was estimated to be 128,000. 2 Despite enormous advancements in the field of diagnostics and therapeutics, the overall survival rate in most countries ranges between 45. Oral squamous cell carcinoma (OSCC) has been one of the most malignant cancers in head and neck region. Anlotinib is a tyrosine kinase inhibitor targeting several receptors such as vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and c-Kit. Here we investigated whether Anlotinib have any antitumor.

Oral squamous cell carcinoma (OSCC), accounting for >90% of all oral cancer cases, is a leading cause of disease-specific mortality, as recently reported in the 8th Edition of the American Joint. Oral cancer (squamous cell carcinoma) is usually treated with surgery alone, or in combination with adjunctive therapy, including radiation, with or without chemotherapy. [33] ( pp602 ) With small lesions (T1), surgery or radiation have similar control rates, so the decision about which to use is based on functional outcome, and complication rates Oral squamous cell carcinoma (SCC) is the second most common oral tumor in dogs. SCCs are typically classified into two. categories: tonsillar SCC (cancer affecting the tonsils) and non-tonsillar SCC (cancer affecting other structures, such as the. gums and tongue). It is estimated that 50-78% of oral SCCs are non-tonsillar

Squamous cells are a type of flat epithelial cell found throughout the body, including in the mouth, on the lips, and on the cervix. They are also seen in the middle layers of the skin. Squamous cell carcinoma is a type of cancer that affects the squamous layers of the epithelium Oral squamous cell carcinoma (OSCC) is the most relevant tumour in the head and neck region to its high prevalence and aggressiveness [1, 2].Despite all developments in cancer treatment, OSCC still have a poor prognosis [1, 2] specially in advanced stages, and a better understanding of the signalling pathways that lead to tumour invasiveness can be fundamental to develop better therapies

Oral epithelial tumorBiomarkers for oral cancerOral cancer seminar

Oral squamous cell carcinoma (OSCC) is the most frequently occurring malignant tumor of the head and neck region. Chk2 (Checkpoint kinase 2) is considered a tumor suppressor gene that acts on the cellular response to DNA damage. However, the role of Chk2 in OSCC prognosis is not yet fully understood. The objective of this study was to evaluate Chk2 immunoexpression in OSCC and to elucidate the. Oral squamous cell carcinoma (OSCC) is the most common type of head and neck squamous cell carcinoma (HNSCC), and the effect of zymosan (ZYM), a component of the yeast cell wall, on oral cancer remains unclear. The CCK-8 proliferation assay was performed to evaluate the effect of ZYM on the proliferation of the OSCC cell lines WSU-HN4, WSU-HN6 and CAL27, and the potential mechanism was. Squamous cell carcinoma (SCC) of oral and oropharyngeal regions (OSCC & OPSCC) are the most common neoplasms of head and neck with a worldwide incidence of 200,000 new cases annually [].OSCC is an extremely aggressive neoplasm with high prevalence among males and is typically preceded by oral leukoplakia (OL) [].Besides tobacco use and alcohol consumption, HPV (human papillomavirus) has also. Microbial dysbiosis in the upper digestive tract is linked to an increased risk of esophageal squamous cell carcinoma (ESCC); this study shows that invasion of the bacterium Porphyromonas gingivalis enhances the aggressive progression of ESCC via the TGFβ/Smad and TGFβ/YAP/TAZ pathways. Targeting P. gingivalis or its activated effectors may provide novel avenues into clinical management of ESCC

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